Expression of Fas system-related genes in the testis during development and after toxicant exposure

被引：37

作者：

Boekelheide, K ^{[1
]}

Lee, J ^{[1
]}

Shipp, EB ^{[1
]}

Richburg, JH ^{[1
]}

Li, G ^{[1
]}

机构：

[1] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA

来源：

TOXICOLOGY LETTERS | 1998年 / 103卷

关键词：

testis; apoptosis; Sertoli cell; germ cell; Fas system;

D O I：

10.1016/S0378-4274(98)00242-2

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The Fas system has been identified as a key regulator of testicular germ cell apoptosis. The goal of these experiments was to explore the expression of Fas system-related genes in the testis during development and after toxicant exposure. Both Fas ligand (FasL) and Fas receptor (Fas) were expressed postnatally in rat testis with peak expression associated with the high levels of germ cell apoptosis found during the first wave of spermatogenesis. The testicular expression of RIP and FAP-1, components of the Pas activating complex, increased after exposure to mono-(2-ethylhexyl)phthalate (MEHP), a Sertoli cell toxicant which induces massive germ cell death. Finally, the expression of additional apoptosis-inducing genes, including tumor necrosis factor receptor (TNFR), FADD, TRAIL, and DR5, was detected in mammalian testis. These results provide additional support for the following concepts: (1) Sertoli-germ cell interactions are important in the control of germ cell apoptosis; and (2) the Fas system and similar paracrine systems are important modulators of testicular homeostasis. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：503 / 508

页数：6

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