The nuclear receptor superfamily and drug discovery

被引：117

作者：

Moore, John T. ^{[1
]}

Collins, Jon L. ^{[1
]}

Pearce, Kenneth H. ^{[1
]}

机构：

[1] GlaxoSmithKline Discovery Res, Dept High Throughout Biol, Res Triangle Pk, NC 27709 USA

来源：

CHEMMEDCHEM | 2006年 / 1卷 / 05期

关键词：

Drug design; Gene expression; Inhibitors; Medicinal chemistry; Receptors;

D O I：

10.1002/cmdc.200600006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Targeting the nuclear receptors: The ligand-binding domain of the glucocorticoid receptor (ribbon) bound with the ligand, dexamethasone (space-filling) is just one of the many pictures that are becoming clearer in the field of nuclear receptor (NR) research. Recent developments in drug discovery show great promise for the treatment of many NR-related diseases.

引用

页码：504 / +

页数：21

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