Chemical reactivity measurement and the predictive identification of skin sensitisers

被引：113

作者：

Gerberick, Frank ^{[5
]}

Aleksic, Maja ^{[2
]}

Basketter, David ^{[3
]}

Casati, Silvia ^{[1
]}

Karlberg, Ann-Therese ^{[4
]}

Kern, Petra ^{[6
]}

Kimber, Ian ^{[7
]}

Lepoittevin, Jean Pierre ^{[8
]}

Natsch, Andreas ^{[9
]}

Ovigne, Jean Marc ^{[10
]}

Rovida, Costanza ^{[1
]}

Sakaguchi, Hitoshi ^{[11
]}

Schultz, Terry ^{[12
]}

机构：

[1] European Commiss Joint Res Ctr, IHCP, ECVAM, I-21027 Ispra, Italy

[2] Safety & Environm Assurance Ctr, Sharnbrook, Beds, England

[3] St Thomas Hosp, St Johns Inst Dermatol, London, England

[4] Univ Gothenburg, Dept Chem, Gothenburg, Sweden

[5] Procter & Gamble Co, Miami Valley Labs, Cincinnati, OH 45253 USA

[6] Procter & Gamble Co, P&G Eurocor, Strombeek Bever, Belgium

[7] Univ Manchester, Fac Life Sci, Manchester, Lancs, England

[8] Univ Strasbourg, Lab Dermatochim, Strasbourg, France

[9] Givaudan Schweiz AG, Dubendorf, Switzerland

[10] LOreal, Aulnay Sous Bois, France

[11] Safety & Microbial Kao Corp, Global R&D, Haga Gun, Japan

[12] Lab Coll Vet Med, Knoxville, TN USA

来源：

ATLA-ALTERNATIVES TO LABORATORY ANIMALS | 2008年 / 36卷 / 02期

关键词：

D O I：

10.1177/026119290803600210

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

引用

页码：215 / 242

页数：28

共 125 条

[1]

AEBY P, 2007, TOXICOLOGIST, V96, P248

[2] Reactivity of contact allergenic haptens to amino acid residues in a model carrier peptide, and characterization of formed peptide-hapten adducts [J].

Ahlfors, SR ;

Sterner, O ;

Hansson, C .

SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY, 2003, 16 (01) :59-68

[3] Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein [J].

Aleksic, Maja ;

Pease, Camilla K. ;

Basketter, David A. ;

Panico, Maria ;

Morris, Howard R. ;

Dell, Anne .

TOXICOLOGY IN VITRO, 2007, 21 (04) :723-733

[4] Effect of glutathione on the covalent binding of the 13C-labeled skin sensitizer 5-chloro-2-methylisothiazol-3-one to human serum albumin:: Identification of adducts by nuclear magnetlic resonance, matrix-assisted laser desorption/ionization mass spectrometry, and nanoelectrospray tandem mass spectrometry [J].

Alvarez-Sánchez, R ;

Divkovic, M ;

Basketter, D ;

Pease, C ;

Panico, M ;

Dell, A ;

Morris, H ;

Lepoittevin, JP .

CHEMICAL RESEARCH IN TOXICOLOGY, 2004, 17 (09) :1280-1288

[5] Covalent binding of the 13C-labeled skin sensitizers 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI) to a model peptide and glutathione [J].

Alvarez-Sánchez, R ;

Basketter, D ;

Pease, C ;

Lepoittevin, JP .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (02) :365-368

[6] Studies of chemical selectivity of hapten, reactivity, and skin sensitization potency.: 3.: Synthesis and studies on the reactivity toward model nucleophiles of the 13C-Labeled skin sensitizers, 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI) [J].

Alvarez-Sánchez, R ;

Basketter, D ;

Pease, C ;

Lepoittevin, JP .

CHEMICAL RESEARCH IN TOXICOLOGY, 2003, 16 (05) :627-636

[7]

[Anonymous], ALT LAB ANIMALS

[8]

[Anonymous], 1982, ALLERGIC CONTACT DER

[9]

API AM, 2008, REGULATORY IN PRESS

[10] Non-enzymatic glutathione reactivity and in vitro toxicity: A non-animal approach to skin sensitization [J].

Aptula, AO ;

Patlewicz, G ;

Roberts, DW ;

Schultz, TW .

TOXICOLOGY IN VITRO, 2006, 20 (02) :239-247

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