Intestinal mucosal tolerance and impact of gut microbiota to mucosal tolerance

被引：70

作者：

Chistiakov, Dimitry A. ^{[1
,2
,3
]}

Bobryshev, Yuri V. ^{[4
,5
,6
]}

Kozarov, Emil ^{[7
]}

Sobenin, Igor A. ^{[4
,7
,8
]}

Orekhov, Alexander N. ^{[4
]}

机构：

[1] Pirogov Russian State Med Univ, Dept Med Nanobiotechnol, Moscow, Russia

[2] Mt Sinai Med Ctr, Mt Sinai Comprehens Canc Ctr, Mt Sinai Community Clin Oncol Program, Miami Beach, FL 33140 USA

[3] Res Ctr Childrens Hlth, Moscow, Russia

[4] Russian Acad Sci, Inst Gen Pathol & Pathophysiol, Moscow, Russia

[5] Univ New S Wales, Fac Med, Sch Med Sci, Sydney, NSW 2052, Australia

[6] Univ Western Sydney Macarthur, Sch Med, Campbelltown, NSW 2560, Australia

[7] Columbia Univ, Dept Oral & Diagnost Sci, New York, NY USA

[8] Russian Cardiol Res & Prod Complex, Med Genet Lab, Moscow, Russia

来源：

FRONTIERS IN MICROBIOLOGY | 2015年 / 5卷

基金：

俄罗斯科学基金会;

关键词：

intestinal microbiota; immune system; microflora; tolerance; harmful antigens; REGULATORY T-CELLS; CD103(+) DENDRITIC CELLS; MESENTERIC LYMPH-NODES; ORAL TOLERANCE; RETINOIC ACID; IMMUNE-RESPONSES; FOXP3(+); INDUCTION; ANTIGEN; HOMEOSTASIS;

D O I：

10.3389/fmicb.2014.00781

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

The mucosal barriers are very sensitive to pathogenic infection, thereby assuming the capacity of the mucosal immune system to induce protective immunity to harmful antigens and tolerance against harmless substances. This review provides current information about mechanisms of induction of mucosal tolerance and about impact of gut microbiota to mucosal tolerance.

引用

页数：9

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