Filamins as integrators of cell mechanics and signalling

被引：838

作者：

Stossel, TP

Condeelis, J

Cooley, L

Hartwig, JH

Noegel, A

Schleicher, M

Shapiro, SS

机构：

[1] Brigham & Womens Hosp, Boston, MA 02115 USA

[2] Yeshiva Univ Albert Einstein Coll Med, Bronx, NY 10461 USA

[3] Yale Univ, Sch Med, New Haven, CT 06520 USA

[4] Univ Cologne, D-50931 Cologne, Germany

[5] Univ Munich, D-80336 Munich, Germany

[6] Thomas Jefferson Univ, Jefferson Med Coll, Philadelphia, PA 19107 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 02期

关键词：

D O I：

10.1038/35052082

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.

引用

页码：138 / 145

页数：8

共 101 条

[1] Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation [J].