Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin

被引：202

作者：

DePianto, Daryle ^{[1
]}

Kerns, Michelle L. ^{[1
]}

Dlugosz, Andrzej A. ^{[2
,3
]}

Coulombe, Pierre A. ^{[1
,4
,5
]}

机构：

[1] Johns Hopkins Univ, Dept Biochem & Mol Biol, Bloomberg Sch Publ Hlth, Baltimore, MD 21218 USA

[2] Univ Michigan, Sch Med, Dept Dermatol, Ann Arbor, MI USA

[3] Univ Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI USA

[4] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21205 USA

来源：

NATURE GENETICS | 2010年 / 42卷 / 10期

基金：

美国国家卫生研究院;

关键词：

BASAL-CELL CARCINOMAS; CUTANEOUS INFLAMMATION; GENE-EXPRESSION; HAIR FOLLICLE; CARCINOGENESIS; HEDGEHOG; TRANSCRIPTION; PROTEINS; DISTINCT; BARRIER;

D O I：

10.1038/ng.665

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Basaloid skin tumors, including basal cell carcinoma (BCC) and basaloid follicular hamartoma, are associated with aberrant Hedgehog (Hh) signaling(1) and, in the case of BCC, an expanding set of genetic variants including keratin 5 (encoded by KRT5)(2), an intermediate filament-forming protein. We here show that genetic ablation of keratin 17 (Krt17) protein, which is induced in basaloid skin tumors(3,4) and co-polymerizes with Krt5 in vivo(5), delays basaloid follicular hamartoma tumor initiation and growth in mice with constitutive Hh signaling in epidermis(6,7). This delay is preceded by a reduced inflammation and a polarization of inflammatory cytokines from a Th1-and Th17-dominated profile to a Th2-dominated profile. Absence of Krt17 also attenuates hyperplasia and inflammation in models of acute dermatitis. Re-expression of Krt17 in Gli2(tg); Krt17(-/-) keratinocytes induces select Th1 chemokines that have established roles in BCC. Our findings establish an immunomodulatory

引用

页码：910 / +

页数：6

共 41 条

[1] Science commentary: Th1 and Th2 responses: what are they? [J].