Posterior subcapsular cataracts, bruises and hoarseness in children with asthma receiving long-term treatment with inhaled budesonide

被引:50
作者
Agertoft, L [1 ]
Larsen, FE [1 ]
Pedersen, S [1 ]
机构
[1] Kolding Hosp, Dept Paediat, DK-6000 Kolding, Denmark
关键词
bruises; cataracts; children; hoarseness; inhaled steroids;
D O I
10.1183/09031936.98.12010130
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
We assessed the effect of long-term treatment with inhaled budesonide (BUD) on the occurrence of posterior subcapsular cataracts (PSC), bruises and hoarseness in children with asthma, Slit lamp examinations were performed in 157 asthmatic children treated with inhaled BUD at a mean daily dose of 504 mu g (range 189-1,322 mu g) for 3-6 yrs (mean 4.4 yrs), Measurements were compared with 111 age-matched children with asthma, who had never received treatment of exogenous corticosteroids (control group). The children were examined for bruises, their tendency to bruise and occurrence of voice changes. No incidents of PSC ascribable to BUD treatment were seen. One patient in the BUD group had been diagnosed with PSC before the study and this was still present. There were no statistically significant differences in number of bruises between the two groups (BUD=3.3, controls=3.2; p=0.70), area covered by bruises (BUD=10 cm(2), controls=10.1 cm(2); p=0.97), tendency to bruise (BUD=5/10, controls=5/10) or occurrence of hoarseness (BUD=20%, controls=21%; p=0.92), Furthermore, there was no correlation between the occurrence of bruises or tendency to bruise and duration of treatment, accumulated or current dose of BUD. A 3-6 yr treatment of children with inhaled budesonide at an average daily dose of about 500 mu g is not associated with an increased occurrence of posterior subcapsular cataract, bruises, tendency to bruise, hoarseness or other noticeable voice changes.
引用
收藏
页码:130 / 135
页数:6
相关论文
共 35 条
[1]   POSTERIOR SUBCAPSULAR CATARACT AND INHALED CORTICOSTEROID-THERAPY [J].
ABUEKTEISH, F ;
KIRKPATRICK, JNP ;
RUSSELL, G .
THORAX, 1995, 50 (06) :674-676
[2]   EFFECTS OF LONG-TERM TREATMENT WITH AN INHALED CORTICOSTEROID ON GROWTH AND PULMONARY-FUNCTION IN ASTHMATIC-CHILDREN [J].
AGERTOFT, L ;
PEDERSEN, S .
RESPIRATORY MEDICINE, 1994, 88 (05) :373-381
[3]   OCULAR FINDINGS IN ATOPIC-DERMATITIS WITH SPECIAL REFERENCE TO THE CLINICAL-FEATURES OF ATOPIC CATARACT [J].
AMEMIYA, T ;
MATSUDA, H ;
UEHARA, M .
OPHTHALMOLOGICA, 1980, 180 (03) :129-132
[4]  
BARNES PJ, 1993, AM REV RESPIR DIS, V148, P1
[5]  
BHAGAT RG, 1984, PEDIATRICS, V73, P626
[6]   Bone and collagen turnover during treatment with inhaled dry powder budesonide and beclomethasone dipropionate [J].
Birkebaek, NH ;
Esberg, G ;
Andersen, K ;
Wolthers, O ;
Hassager, C .
ARCHIVES OF DISEASE IN CHILDHOOD, 1995, 73 (06) :524-527
[7]   ATOPIC CATARACTS VERSUS STEROID CATARACTS [J].
CASTROW, FF .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1981, 5 (01) :64-66
[8]  
DEWAR MH, 1996, THORAX, V51, pA74
[9]   Allergic respiratory disease: Strategic targets for primary prevention during childhood [J].
Holt, PG ;
Sly, PD .
THORAX, 1997, 52 (01) :1-4
[10]  
Hone S W, 1996, Rev Laryngol Otol Rhinol (Bord), V117, P331