Successful treatment of resistant pseudogout with anakinra

被引：87

作者：

McGonagle, Dennis ^{[1
,2
]}

Tan, Ai Lyn ^{[1
]}

Madden, Julie ^{[2
]}

Emery, Paul ^{[1
]}

McDermott, Michael F. ^{[3
]}

机构：

[1] Univ Leeds, Chapel Allerton Hosp, Acad Unit Musculoskeletal Dis, Leeds LS7 4SA, W Yorkshire, England

[2] Calderdale Royal Hosp, Halifax, England

[3] St James Univ Hosp, Leeds Inst Mol Med, Leeds LS9 7TF, W Yorkshire, England

来源：

ARTHRITIS AND RHEUMATISM | 2008年 / 58卷 / 02期

关键词：

D O I：

10.1002/art.23119

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We describe herein the case of a 63-year-old man with pseudogout affecting multiple joints that was resistant to treatment with allopurinol, steroids, and antiinflammatory drugs. Based on recent data on the molecular mechanism of pseudogout that demonstrated overproduction of interleukin-1 (IL-1), we treated the patient with anakinra, an IL-1 receptor antagonist. The patient responded to treatment with anakinra within 2 weeks, with resolution of the signs and symptoms of pseudogout and normalization of levels of inflammation markers.

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收藏

页码：631 / 633

页数：3

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