Results of a phase I dendritic cell vaccine trial for malignant astrocytoma: potential interaction with adjuvant chemotherapy

被引：62

作者：

Walker, David G. ^{[1
,2
]}

Laherty, Richard ^{[1
,2
]}

Tomlinson, Frank H. ^{[2
]}

Chuah, Teong ^{[2
]}

Schmidt, Chris ^{[2
]}

机构：

[1] Royal Brisbane & Womens Hosp, Dept Neurosurg, Brisbane, Qld, Australia

[2] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2008年 / 15卷 / 02期

关键词：

astrocytoma; glioblastoma; dendritic cell; vaccination; immunotherapy;

D O I：

10.1016/j.jocn.2007.08.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Dendritic cell vaccination has been applied to the treatment of a variety of cancers, including malignant astrocytoma. We have treated 13 patients with malignant astrocytoma using dendritic cell vaccination and have shown that this treatment is safe and is likely to be effective in combination with standard adjuvant therapy. Future studies should prospectively incorporate dendritic cell vaccination together with chemotherapy. Ideally, dendritic cell vaccination should be tested in a prospective fashion, in a coordinated trial involving multiple centres. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：114 / 121

页数：8

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