Regulation of virulence gene expression in Shigella flexneri, a facultative intracellular pathogen

被引：51

作者：

Dorman, CJ ^{[1
]}

McKenna, S ^{[1
]}

Beloin, C ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Dept Microbiol, Moyne Inst Prevent Med, Dublin 2, Ireland

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2001年 / 291卷 / 02期

关键词：

Shigella; gene regulation; virulence plasmid; regulatory cascade;

D O I：

10.1078/1438-4221-00105

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Shigella flexneri and its close relatives are facultative intracellular pathogens of humans and are the etiological agents of bacillary dysentery. These bacteria secrete proteins that enable them to enter human epithelial cells via an elaborate and fascinating cell biology. This behaviour depends on a complicated regulon of virulence genes, whose expression is controlled in response to a multiplicity of environmental signals. This review describes and attempts to interpret these gene control mechanisms.

引用

页码：89 / 96

页数：8

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