Diminished plasma levels of vitamin E in patients with severe viral hepatitis

被引：27

作者：

vonHerbay, A

Stahl, W

Niederau, C

vonLaar, J

Strohmeyer, G

Sies, H

机构：

[1] UNIV DUSSELDORF,DEPT MED,GI UNIT,D-4000 DUSSELDORF,GERMANY

[2] UNIV DUSSELDORF,DEPT PHYSIOL CHEM 1,D-4000 DUSSELDORF,GERMANY

来源：

FREE RADICAL RESEARCH | 1996年 / 25卷 / 06期

关键词：

alpha-tocopherol; vitamin E; liver; viral hepatitis; free radicals; antioxidants; oxidative stress;

D O I：

10.3109/10715769609149068

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RRR-alpha-Tocopherol (Vitamin E) was assayed in plasma of 48 patients with viral hepatitis and of 32 healthy controls. In patients with highly elevated serum transaminases (ALT >100 U/L) vitamin E plasma levels were significantly lower (17.5 +/- 4.8 mu mol/L) than in controls (22.7 +/- 4.2 mu mol/L, p < 0.01). The vitamin E/ lipid ratios (3.12 +/- 0.63 mu mol/g) in these patients were 33% lower than those of the controls (4.68 +/- 0.54 mu mol/g). The lowered vitamin E levels in patients with acute or chronic viral hepatitis with high activity of disease may be due to free radical-mediated liver injury.

引用

页码：461 / 466

页数：6

共 24 条

[1] THE PATHOLOGY OF HEPATIC IRON OVERLOAD - A FREE-RADICAL MEDIATED PROCESS [J].