A meta-analysis of the effects of aging on motor cortex neurophysiology assessed by transcranial magnetic stimulation

被引：121

作者：

Bhandari, Apoorva ^{[1
]}

Radhu, Natasha ^{[1
]}

Farzan, Faranak ^{[1
,2
,3
]}

Mulsant, Benoit H. ^{[1
,2
,3
]}

Rajji, Tarek K. ^{[1
,2
,3
]}

Daskalakis, Zafiris J. ^{[1
,2
,3
]}

Blumberger, Daniel M. ^{[1
,2
,3
]}

机构：

[1] Ctr Addict & Mental Hlth, Temerty Ctr Therapeut Brain Intervent, 1001 Queen St W,Unit 4,Room 115, Toronto, ON M6J 1H4, Canada

[2] Univ Toronto, Dept Psychiat, Toronto, ON M5T 1R8, Canada

[3] Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Toronto, ON M5T 1R8, Canada

来源：

CLINICAL NEUROPHYSIOLOGY | 2016年 / 127卷 / 08期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

Aging; Transcranial magnetic stimulation; Motor cortex; Cortical plasticity; Cortical excitability; Gamma-aminobutyric acid; AGE-RELATED DIFFERENCES; INTERVAL INTRACORTICAL INHIBITION; NONINVASIVE BRAIN-STIMULATION; LATENCY AFFERENT INHIBITION; LONG-TERM POTENTIATION; CORTICAL PLASTICITY; CORTICOSPINAL EXCITABILITY; CORTICOMOTOR EXCITABILITY; DEPENDENT PLASTICITY; CHOLINERGIC SYSTEM;

D O I：

10.1016/j.clinph.2016.05.363

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Objective: Transcranial magnetic stimulation (TMS) is a non-invasive tool used for studying cortical excitability and plasticity in the human brain. This review aims to quantitatively synthesize the literature on age-related differences in cortical excitability and plasticity, examined by TMS. Methods: A literature search was conducted using MEDLINE, Embase, and PsycINFO from 1980 to December 2015. We extracted studies with healthy old (50-89 years) versus young (16-49 years) individuals that utilized the following TMS measures: resting motor threshold (RMT), short-interval cortical inhibition (SICI), short-latency afferent inhibition (SAI), cortical silent period (CSP), intracortical facilitation (ICF), and paired associative stimulation (PAS). Results: We found a significant increase in RMT (g = 0.414, 95% confidence interval (CI) [0.284, 0.544], p < 0.001), a significant decrease in SAI (g = 0.778, 95% CI [0.478, 1.078], p < 0.001), and a trending decrease in LTP-like plasticity (g = -0.528, 95% CI [-1.157, 0.100] p < 0.1) with age. Conclusions: Our findings suggest an age-dependent reduction in cortical excitability and sensorimotor integration within the human motor cortex. Significance: Alterations in the ability to regulate cortical excitability, sensorimotor integration and plasticity may underlie several age-related motor deficits. (C) 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：2834 / 2845

页数：12

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