Tight junctions and the modulation of barrier function in disease

被引：557

作者：

Foerster, Carola ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Anat & Cell Biol, D-97070 Wurzburg, Germany

来源：

HISTOCHEMISTRY AND CELL BIOLOGY | 2008年 / 130卷 / 01期

关键词：

tight junction; occludin; claudin; cancer; inflammation; toxin; hereditary; vascular;

D O I：

10.1007/s00418-008-0424-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Tight junctions create a paracellular barrier in epithelial and endothelial cells protecting them from the external environment. Two different classes of integral membrane proteins constitute the tight junction strands in epithelial cells and endothelial cells, occludin and members of the claudin protein family. In addition, cytoplasmic scaffolding molecules associated with these junctions regulate diverse physiological processes like proliferation, cell polarity and regulated diffusion. In many diseases, disruption of this regulated barrier occurs. This review will briefly describe the molecular composition of the tight junctions and then present evidence of the link between tight junction dysfunction and disease.

引用

页码：55 / 70

页数：16

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