Serotonin and autism: Biochemical and molecular biology features

被引：45

作者：

Herault, J

Petit, E

Martineau, J

Cherpi, C

Perrot, A

Barthelemy, C

Lelord, G

Muh, JP

机构：

[1] CHU BRETONNEAU,INSERM,U316,SERV UNIV EXPLORAT FONCT & NEUROPHYSIOL PEDOPSYCH,F-37044 TOURS,FRANCE

[2] CHU BRETONNEAU,INSERM,U316,SERV UNIV PEDOPSYCHIAT,F-37044 TOURS,FRANCE

来源：

PSYCHIATRY RESEARCH | 1996年 / 65卷 / 01期

关键词：

genetics; 5-hydroxytryptamine(2A) receptor; 5-hydroxyindoleacetic acid; child psychiatry;

D O I：

10.1016/0165-1781(96)02882-X

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Whole blood and urinary levels of serotonin (5-hydroxytryptamine; 5-HT) and the derivative urinary 5-hydroxyindoleacetic acid (5-HIAA) were measured in normal and autistic subjects. An association was tested between autism and a marker coding for the 5-HT2A serotonergic receptor gene. Significant group (high urinary 5-HT and low whole blood 5-HT in autism) and age effects (urinary 5-HT decrease with age) were found. Moreover, whole blood 5-HT levels were correlated with clinical state. No differences in allele and genotype frequencies for the 5-HT2A receptor marker were found in this autistic population compared with age-matched healthy students.

引用

页码：33 / 43

页数：11

共 65 条

[1] ELEVATED BLOOD SEROTONIN IN AUTISTIC PROBANDS AND THEIR 1ST-DEGREE RELATIVES [J].