Antioxidants: Strategies for Interventions in Aging and Age-Related Diseases A Workshop Sponsored by the National Institute on Aging and by the Office of Dietary Supplements

被引：7

作者：

Darley-Usmar, Victor ^{[1
]}

Starke-Reed, Pamela E. ^{[2
]}

机构：

[1] Univ Alabama, Dept Pathol, Birmingham, AL 35295 USA

[2] NIDDK, Div Nutr Res Coordinat, NIH, Bethesda, MD 20892 USA

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2000年 / 2卷 / 03期

关键词：

D O I：

10.1089/15230860050192143

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of free radicals in aging has been a long-standing theory that has now been extended to include both reactive oxygen and nitrogen species. The original concepts that overwhelming oxidative stress depleted antioxidants and thus damaged intracellular targets is being supplanted by the hypothesis that the reactive species play an essential role in signal transduction. The concept that the cell establishes a redox tone that is altered during the aging process places the oxidative and nitrosative modifications that occur during aging in a new and exciting context. Some highlights of this recent workshop convened by The National Institute on Aging and the Office of Dietary Supplements at the National Institutes of Health are discussed. Antiox. & Redox Signal. 2, 375-378.

引用

页码：375 / 377

页数：3