Pluripotent Stem Cell-Based Cancer Therapy: Promise and Challenges

被引：45

作者：

Sharkis, Saul J. ^{[1
]}

Jones, Richard J. ^{[1
]}

Civin, Curt ^{[2
]}

Jang, Yoon-Young ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD 21231 USA

[2] Univ Maryland, Sch Med, Ctr Stem Cell Biol & Regenerat Med, Baltimore, MD 21201 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2012年 / 4卷 / 127期

关键词：

BONE-MARROW-TRANSPLANTATION; HEMATOLOGIC MALIGNANCIES; EPIGENETIC MEMORY; BLOOD-CELLS; T-CELL; GENERATION; DIFFERENTIATION; ENDODERM; LEUKEMIA; DONORS;

D O I：

10.1126/scitranslmed.3003920

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The development of induced pluripotent stem cell (iPSC) technology has generated enthusiasm about the therapeutic potential of these cells for treating a variety of diseases. However, the evidence that they actually will be clinically useful is limited. Here, we discuss the potential therapeutic applications of iPSCs for treating cancer and other diseases and highlight the current barriers restricting their use.

引用

页数：4

共 37 条

[1] Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells [J].

Bar-Nur, Ori ;

Russ, Holger A. ;

Efrat, Shimon ;

Benvenisty, Nissim .

CELL STEM CELL, 2011, 9 (01) :17-23

[2] Derivation of Induced Pluripotent Stem Cells from Human Peripheral Blood T Lymphocytes [J].

Brown, Matthew E. ;

Rondon, Elizabeth ;

Rajesh, Deepika ;

Mack, Amanda ;

Lewis, Rachel ;

Feng, Xuezhu ;

Zitur, Laura Jo ;

Learish, Randall D. ;

Nuwaysir, Emile F. .

PLOS ONE, 2010, 5 (06)

[3] Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts [J].

Brunstein, Claudio G. ;

Fuchs, Ephraim J. ;

Carter, Shelly L. ;

Karanes, Chatchada ;

Costa, Luciano J. ;

Wu, Juan ;

Devine, Steven M. ;

Wingard, John R. ;

Aljitawi, Omar S. ;

Cutler, Corey S. ;

Jagasia, Madan H. ;

Ballen, Karen K. ;

Eapen, Mary ;

O'Donnell, Paul V. .

BLOOD, 2011, 118 (02) :282-288

[4] Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent stem cells [J].

Choi, Su Mi ;

Liu, Hua ;

Chaudhari, Pooja ;

Kim, Yonghak ;

Cheng, Linzhao ;

Feng, Jian ;

Sharkis, Saul ;

Ye, Zhaohui ;

Jang, Yoon-Young .

BLOOD, 2011, 118 (07) :1801-1805

[5] Liver engraftment potential of hepatic cells derived from patient-specific induced pluripotent stem cells [J].

Choi, Su Mi ;

Kim, Yonghak ;

Liu, Hua ;

Chaudhari, Pooja ;

Ye, Zhaohui ;

Jang, Yoon-Young .

CELL CYCLE, 2011, 10 (15) :2423-2427

[6] Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures [J].

Chou, Bin-Kuan ;

Mali, Prashant ;

Huang, Xiaosong ;

Ye, Zhaohui ;

Dowey, Sarah N. ;

Resar, Linda M. S. ;

Zou, Chunlin ;

Zhang, Y. Alex ;

Tong, Jay ;

Cheng, Linzhao .

CELL RESEARCH, 2011, 21 (03) :518-529

[7]

Chun YS, 2010, INT J BIOL SCI, V6, P796

[8] Paucity of HLA-identical unrelated donors for African-Americans with hematologic malignancies: The need for new donor options [J].

Dew, Alexander ;

Collins, Demetria ;

Artz, Adrew ;

Rich, Elizabeth ;

Stock, Wendy ;

Swanson, Kate ;

van Besien, Koen .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2008, 14 (08) :938-941

[9] Somatic coding mutations in human induced pluripotent stem cells [J].

Gore, Athurva ;

Li, Zhe ;

Fung, Ho-Lim ;

Young, Jessica E. ;

Agarwal, Suneet ;

Antosiewicz-Bourget, Jessica ;

Canto, Isabel ;

Giorgetti, Alessandra ;

Israel, Mason A. ;

Kiskinis, Evangelos ;

Lee, Je-Hyuk ;

Loh, Yuin-Han ;

Manos, Philip D. ;

Montserrat, Nuria ;

Panopoulos, Athanasia D. ;

Ruiz, Sergio ;

Wilbert, Melissa L. ;

Yu, Junying ;

Kirkness, Ewen F. ;

Izpisua Belmonte, Juan Carlos ;

Rossi, Derrick J. ;

Thomson, James A. ;

Eggan, Kevin ;

Daley, George Q. ;

Goldstein, Lawrence S. B. ;

Zhang, Kun .

NATURE, 2011, 471 (7336) :63-U76

[10] Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin [J].

Hanna, Jacob ;

Wernig, Marius ;

Markoulaki, Styliani ;

Sun, Chiao-Wang ;

Meissner, Alexander ;

Cassady, John P. ;

Beard, Caroline ;

Brambrink, Tobias ;

Wu, Li-Chen ;

Townes, Tim M. ;

Jaenisch, Rudolf .

SCIENCE, 2007, 318 (5858) :1920-1923

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