Receptors for gamma-interferon encoded by poxviruses: Implications for the unknown origin of vaccinia virus

被引：31

作者：

Alcami, A ^{[1
]}

Smith, GL ^{[1
]}

机构：

[1] UNIV OXFORD,SIR WILLIAM DUNN SCH PATHOL,OXFORD OX1 3RE,ENGLAND

来源：

TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 08期

关键词：

D O I：

10.1016/0966-842X(96)10051-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Poxviruses encode soluble interferon-gamma receptors (IFN-gamma Rs) that inhibit IFN-gamma activity and play a major role in virus pathogenesis. In contrast to the highly species specific cellular homologues, the vaccinia IFN-gamma R has novel broad species specificity. This has implications for the unknown origin and natural host(s) of vaccinia virus, the vaccine used for smallpox eradication.

引用

页码：321 / 326

页数：6

共 38 条

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