JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow

被引：42

作者：

Arcangeli, Marie-Laure ^{[1
,2
,3
]}

Frontera, Vincent ^{[1
,2
,3
]}

Bardin, Florence ^{[1
,2
,3
]}

Obrados, Elodie ^{[1
,2
,3
]}

Adams, Susanne ^{[4
,5
]}

Chabannon, Christian ^{[2
,3
,6
]}

Schiff, Claudine ^{[3
,7
,8
,9
]}

Mancini, Stephane. J. C. ^{[3
,7
,8
,9
]}

Adams, Ralf H. ^{[4
,5
]}

Aurrand-Lions, Michel ^{[1
,2
,3
]}

机构：

[1] INSERM, Ctr Res Cancerol Marseille, UMR 891, F-13273 Marseille 09, France

[2] Inst Paoli Calmettes, Marseille, France

[3] Univ Mediterranee, Marseille, France

[4] Univ Munster, Dept Tissue Morphogenesis, Max Planck Inst Mol Biomed, Munster, Germany

[5] Univ Munster, Fac Med, Munster, Germany

[6] INSERM, CBT 510, Ctr Invest Clin Biotherapie, F-13273 Marseille 09, France

[7] Ctr Immunol Marseille Luminy, Marseille, France

[8] INSERM, UMR 631, F-13273 Marseille 09, France

[9] Ctr Natl Rech Sci, UMR 6102, Marseille, France

来源：

BLOOD | 2011年 / 118卷 / 17期

基金：

瑞士国家科学基金会;

关键词：

JUNCTIONAL ADHESION MOLECULE; PROGENITOR CELLS; IMMUNOGLOBULIN SUPERFAMILY; NICHE; MOBILIZATION; HETEROGENEITY; POPULATIONS; MODULATION; INTERACTS; AMD3100;

D O I：

10.1182/blood-2010-12-323972

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In adult mammals, hematopoietic stem cells (HSCs) reside in the bone marrow (BM) and are maintained in a quiescent and undifferentiated state through adhesive interactions with specialized microenvironmental niches. Although junctional adhesion molecule-C (JAM-C) is expressed by HSCs, its function in adult hematopoiesis remains elusive. Here, we show that HSCs adhere to JAM-B expressed by BM stromal cells in a JAM-C dependent manner. The interaction regulates the interplay between HSCs and BM stromal cells as illustrated by the decreased pool of quiescent HSCs observed in jam-b deficient mice. We further show that this is probably because of alterations of BM stromal compartments and changes in SDF-1 alpha BM content in jam-b(-/-) mice, suggesting that JAM-B is an active player in the maintenance of the BM stromal microenvironment. (Blood. 2011; 118(17): 4609-4619)

引用

页码：4609 / 4619

页数：11

共 51 条

[1] Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche [J].