Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory

被引:11
作者
Annemie, Van Dijck [1 ]
Ellen, Vloeberghs [1 ]
Debby, Van Dam [1 ]
Matthias, Staufenbiel [2 ]
Paul, De Deyn Peter [1 ,3 ]
机构
[1] Univ Antwerp, Lab Neurochem & Behav, Inst Born Bunge, Dept Biomed Sci, B-2610 Antwerp, Belgium
[2] Novartis Inst Biomed Res Basel, CH-4002 Basel, Switzerland
[3] Middelheim Hosp, ZNA, Dept Neurol, Memory Clin, B-2020 Antwerp, Belgium
关键词
APP23; Alzheimer's disease; memory; paired-associate test; cognitive; non-spatial; odour;
D O I
10.1016/j.bbr.2008.02.014
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];
摘要
The APP23 model is a transgenic mouse model for Alzheimer's disease. Cognitive performance in the APP23-model was assessed by Morris Water Maze (MWM) and passive avoidance learning, but the latter failed to show any difference between the genotypes. In search of a non-spatial alternative for assessment of hippocampus-dependent memory, we evaluated an odour paired-associate test, which is based on learning an association between two sets of odours. The protocol includes a shaping phase, in which the animals learn to dig up a reward, a preliminary training phase and a training phase, where the actual association is learned. Subsequently, mice are tested for transitive inference and subjected to a symmetry test. Impairment was seen in the APP23 mice, in comparison with wild type mice, in training; however, both groups failed the transitivity and symmetry test. Possible explanations for this discrepancy with earlier published results are the advanced age of the mice or the C57B1/6J background, in which the model was established. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:147 / 151
页数:5
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