Protective Effects of Radon Inhalation on Carrageenan-Induced Inflammatory Paw Edema in Mice

被引：40

作者：

Kataoka, Takahiro ^{[1
]}

Teraoka, Junichi ^{[1
]}

Sakoda, Akihiro ^{[2
]}

Nishiyama, Yuichi ^{[1
]}

Yamato, Keiko ^{[1
]}

Monden, Mayuko ^{[3
]}

Ishimori, Yuu ^{[2
]}

Nomura, Takaharu ^{[4
]}

Taguchi, Takehito ^{[1
]}

Yamaoka, Kiyonori ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Hlth Sci, Kita Ku, Okayama 7008558, Japan

[2] Japan Atom Energy Agcy, Ningyo Toge Environm Engn Ctr, Okayama 7080698, Japan

[3] Fukuyama Univ, Fac Pharm & Pharmaceut Sci, Dept Pharmacol, Fukuyama, Hiroshima 7290292, Japan

[4] Cent Res Inst Elect Power Ind, Radiat Safety Res Ctr, Komae, Tokyo 2018511, Japan

来源：

INFLAMMATION | 2012年 / 35卷 / 02期

关键词：

radon inhalation; inflammation; carrageenan; edema; antioxidative function; GAMMA-RAY IRRADIATION; DOSE X-IRRADIATION; THERMAL THERAPY; GLUTATHIONE; PEROXIDE;

D O I：

10.1007/s10753-011-9364-y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m(3) of radon for 24 h. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activities and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activates antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-alpha) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-alpha levels were lower in the radon-treated mice than in sham-treated mice. In addition, SOD and catalase activities in paws were significantly higher in the radon-treated mice than in the sham-treated mice. These findings indicated that radon inhalation had anti-inflammatory effects and inhibited carrageenan-induced inflammatory paw edema.

引用

页码：713 / 722

页数：10

共 27 条

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