Eph-ephrin signalling in adult tissues and cancer

被引：107

作者：

Merlos-Suarez, Anna ^{[1
]}

Batlle, Eduard ^{[1
,2
]}

机构：

[1] IRB, Oncol Program, Barcelona 08028, Spain

[2] Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain

来源：

CURRENT OPINION IN CELL BIOLOGY | 2008年 / 20卷 / 02期

关键词：

D O I：

10.1016/j.ceb.2008.01.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eph receptor tyrosine kinases and their ligands, the ephrins, play key roles in the regulation of migration and cell adhesion during development, thereby influencing cell fate, morphogenesis and organogenesis. Recent findings suggest that Eph signalling also controls the architecture and physiology of different tissues in the adult body under normal and pathological conditions such as cancer. A prime example is the intestinal epithelium where EphB-ephrinB interactions regulate both cell positioning and tumor progression. Here, we will review recent advances on the role of Eph-ephrin signalling in the intestine and other organs.

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页码：194 / 200

页数：7

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