TOR in the immune system

被引：107

作者：

Araki, Koichi

Ellebedy, Ali H.

Ahmed, Rafi ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2011年 / 23卷 / 06期

基金：

美国国家卫生研究院;

关键词：

T-CELL DIFFERENTIATION; MAMMALIAN TARGET; DENDRITIC CELLS; LIFE-SPAN; MTOR KINASE; SELECTIVE EXPRESSION; REG CELLS; AKT-MTOR; IN-VIVO; B-CELLS;

D O I：

10.1016/j.ceb.2011.08.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The target of rapamycin (TOR) is a crucial intracellular regulator of the immune system. Recent studies have suggested that immunosuppression by TOR inhibition may be mediated by modulating differentiation of both effector and regulatory CD4 T cell subsets. However, it was paradoxically shown that inhibiting TOR signaling has immunostimulatory effects on the generation of long-lived memory CD8 T cells. Beneficial effects of TOR inhibition have also been observed with dendritic cells and hematopoietic stem cells. This immune modulation may contribute to lifespan extension seen in mice with mTOR inhibition. Here, we review recent findings on TOR modulation of innate and adaptive immune responses, and discuss potential applications of regulating TOR to provide longer and healthier immunity.

引用

收藏

页码：707 / 715

页数：9

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