Module extension of a non-ribosomal peptide synthetase of the glycopeptide antibiotic balhimycin produced by Amycolatopsis balhimycina

被引:43
作者
Butz, Diane [1 ]
Schmiederer, Timo [1 ]
Hadatsch, Bianka [2 ]
Wohlleben, Wolfgang [2 ]
Weber, Tilmann [2 ]
Suessmuth, Roderich D. [1 ]
机构
[1] Tech Univ Berlin, Inst Chem, FG Organ Chem, D-10623 Berlin, Germany
[2] Univ Tubingen, Inst Mikrobiol Biotechnol, D-72076 Tubingen, Germany
关键词
combinatorial biosynthesis; genetic engineering; glycopeptides; module extension; non-ribosomal peptide synthetases;
D O I
10.1002/cbic.200800068
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:1195 / 1200
页数:6
相关论文
共 27 条
[1]   Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis [J].
Belshaw, PJ ;
Walsh, CT ;
Stachelhaus, T .
SCIENCE, 1999, 284 (5413) :486-489
[2]  
Bischoff D, 2001, ANGEW CHEM INT EDIT, V40, P4688, DOI 10.1002/1521-3773(20011217)40:24<4688::AID-ANIE4688>3.0.CO
[3]  
2-M
[4]   The biosynthesis of vancomycin-type glycopeptide antibiotics -: A model for oxidative side-chain cross-linking by oxygenases coupled to the action of peptide synthetases [J].
Bischoff, D ;
Bister, B ;
Bertazzo, M ;
Pfeifer, V ;
Stegmann, E ;
Nicholson, GJ ;
Keller, S ;
Pelzer, S ;
Wohlleben, W ;
Süssmuth, RD .
CHEMBIOCHEM, 2005, 6 (02) :267-272
[5]  
Bischoff D., 2001, ANGEW CHEM, V113, P4824
[6]  
Keller U, 2003, COMB CHEM HIGH T SCR, V6, P527
[7]   Characterization of the nodularin synthetase gene cluster and proposed theory of the evolution of cyanobacterial hepatotoxins [J].
Moffitt, MC ;
Neilan, BA .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 70 (11) :6353-6362
[8]  
Mootz HD, 2002, CHEMBIOCHEM, V3, P490, DOI 10.1002/1439-7633(20020603)3:6<490::AID-CBIC490>3.0.CO
[9]  
2-N
[10]   Decreasing the ring size of a cyclic nonribosomal peptide antibiotic by in-frame module deletion in the biosynthetic genes [J].
Mootz, HD ;
Kessler, N ;
Linne, U ;
Eppelmann, K ;
Schwarzer, D ;
Marahiel, MA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (37) :10980-10981