Cortico-cortical connectivity of the human mid-dorsolateral frontal cortex and its modulation by repetitive transcranial magnetic stimulation

被引：276

作者：

Paus, T ^{[1
]}

Castro-Alamancos, MA ^{[1
]}

Petrides, M ^{[1
]}

机构：

[1] McGill Univ, Montreal Neurol Inst, Cognit Neurosci Unit, Montreal, PQ H3A 2B4, Canada

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 2001年 / 14卷 / 08期

关键词：

cingulate; depression; humans; PET;

D O I：

10.1046/j.0953-816x.2001.01757.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Modulation of cortico-cortical connectivity in specific neural circuits might underlie some of the behavioural effects observed following repetitive transcranial magnetic stimulation (rTMS) of the human frontal cortex. This possibility was tested by applying rTMS to the left mid-dorso lateral frontal cortex (MDL-FC) and subsequently measuring functional connectivity of this region with positron emission tomography (PET) and TMS. The results showed a strong rTMS-related modulation of brain activity in the fronto-cingulate circuit. These results were confirmed in a parallel experiment in the rat using electrical stimulation and field-potential recordings. Future studies are needed to provide a direct link between the rTMS-induced modulation of cortical connectivity and its effects on specific behaviours.

引用

页码：1405 / 1411

页数：7

共 39 条

[1] Barbas H, 1992, Adv Neurol, V57, P91
[2] BAXTER LR, 1989, ARCH GEN PSYCHIAT, V46, P243
[3] Chronic repetitive transcranial magnetic stimulation alters β-adrenergic and 5-HT2 receptor characteristics in rat brain
Ben-Shachar, D
Gazawi, H
Riboyad-Levin, J
Klein, E
[J]. BRAIN RESEARCH, 1999, 816 (01) : 78 - 83
[4] THE ANATOMY OF MELANCHOLIA - FOCAL ABNORMALITIES OF CEREBRAL BLOOD-FLOW IN MAJOR DEPRESSION
BENCH, CJ
FRISTON, KJ
BROWN, RG
SCOTT, LC
FRACKOWIAK, RSJ
DOLAN, RJ
[J]. PSYCHOLOGICAL MEDICINE, 1992, 22 (03) : 607 - 615
[5] AUTOMATIC 3D INTERSUBJECT REGISTRATION OF MR VOLUMETRIC DATA IN STANDARDIZED TALAIRACH SPACE
COLLINS, DL
NEELIN, P
PETERS, TM
EVANS, AC
[J]. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1994, 18 (02) : 192 - 205
[6] CONTRIBUTIONS OF ANTERIOR CINGULATE CORTEX TO BEHAVIOUR
DEVINSKY, O
MORRELL, MJ
VOGT, BA
[J]. BRAIN, 1995, 118 : 279 - 306
[7] Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, WC
Price, JL
Simpson, JR
Todd, RD
Reich, T
Vannier, M
Raichle, ME
[J]. NATURE, 1997, 386 (6627) : 824 - 827
[8] Imaging human intra-cerebral connectivity by PET during TMS
Fox, P
Ingham, R
George, MS
Mayberg, H
Ingham, J
Roby, J
Martin, C
Jerabek, P
[J]. NEUROREPORT, 1997, 8 (12) : 2787 - 2791
[9] Modulation of receptive field properties of thalamic somatosensory neurons by the depth of anesthesia
Friedberg, MH
Lee, SM
Ebner, FF
[J]. JOURNAL OF NEUROPHYSIOLOGY, 1999, 81 (05) : 2243 - 2252
[10] Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: A placebo-controlled crossover trial
George, MS
Wassermann, EM
Kimbrell, TA
Little, JT
Williams, WE
Danielson, AL
Greenberg, BD
Hallett, M
Post, RM
[J]. AMERICAN JOURNAL OF PSYCHIATRY, 1997, 154 (12) : 1752 - 1756

← 1 2 3 4 →