Post-genomics of bone metabolic dysfunctions and neoplasias

被引：20

作者：

Bernardini, Giulia ^{[1
]}

Braconi, Daniela ^{[1
]}

Spreafico, Adriano ^{[2
]}

Santucci, Annalisa ^{[1
,2
]}

机构：

[1] Univ Siena, Dipartimento Biotecnol, I-53100 Siena, Italy

[2] Univ Siena, Ctr Interdipartimentale Studio Biochim Patol Oste, I-53100 Siena, Italy

来源：

PROTEOMICS | 2012年 / 12卷 / 4-5期

关键词：

Bone metabolic diseases; Cell biology; Osteoporosis; Osteosarcoma; Post-genomics; COMPARATIVE PROTEOMIC ANALYSIS; GENE-EXPRESSION PROFILES; HUMAN OSTEOSARCOMA CELLS; MARROW STROMAL CELLS; IN-VITRO; PARATHYROID-HORMONE; PAGETS-DISEASE; OSTEOBLASTIC CELL; PEDIATRIC OSTEOSARCOMAS; CIRCULATING MONOCYTES;

D O I：

10.1002/pmic.201100358

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Post-genomic research on osteoblastic and osteoclastic cells, in contrast to that on many other cell types, has only been undertaken recently. Nevertheless, important information has been gained from these investigations on the mechanisms involved in osteoblast differentiation and on markers relevant for tissue regeneration and therapeutic validation of drugs, hormones and growth factors. These protein indicators may also have a diagnostic and prognostic value for bone dysfunctions and tumors. Some reviews have already focused on the application of transcriptomics and/or proteomics for exploring skeletal biology and related disorders. The main goal of the present review is to systematically summarize the most relevant post-genomic studies on various metabolic bone diseases (osteoporosis, Paget's disease and osteonecrosis), neoplasias (osteosarcoma) and metabolic conditions that indirectly affect bone tissue, such as alkaptonuria.

引用

页码：708 / 721

页数：14

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