CDC25A phosphatase: a rate-limiting oncogene that determines genomic stability

被引：67

作者：

Ray, Dipankar ^{[1
,2
]}

Kiyokawa, Hiroaki ^{[1
,2
]}

机构：

[1] Northwestern Univ, Dept Mol Pharmacol & Biol Chem, Chicago, IL 60611 USA

[2] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

来源：

CANCER RESEARCH | 2008年 / 68卷 / 05期

关键词：

D O I：

10.1158/0008-5472.CAN-07-5983

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CDC25A is a critical regulator of cell cycle progression and checkpoint response. Overexpression of this cyclin-dependent kinase phosphatase occurs often in human cancers. Our recent genetic studies in the mouse indicate that restricting CDC25A can limit tumorigenesis induced by the HER2/neuRAS oncogenic pathway without compromising normal cell division or viability. These findings offer a sound foundation to justify development of CDC25A inhibitors for antitumor therapy.

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收藏

页码：1251 / 1253

页数：3

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