Effects of lisinopril on streptozotocin-induced diabetic neuropathy in rats

被引：16

作者：

Aggarwal, M ^{[1
]}

Singh, J

Sood, S

Arora, B

机构：

[1] Postgrad Inst Med Educ & Res, Dept Pharmacol, Chandigarh 160012, India

[2] Postgrad Inst Med Educ & Res, Dept Physiol & Pathol, Chandigarh 160012, India

来源：

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | 2001年 / 23卷 / 03期

关键词：

diabetic neuropathy; lisinopril; streptozotocin;

D O I：

10.1358/mf.2001.23.3.627945

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Streptozotocin (STZ)-induced diabetic neuropathy in rats was monitored by measuring the motor nerve conduction velocity (MNCV) and histopathology of the tibial nerve. Pretreatment with lisinopril (2 mg/kg p.o., 5 days prior to STZ and continued for 10 weeks) significantly (p < 0.01) prevented deterioration of MNCV ms compared to STZ-diabetic animals. Nerve sections from the lisinopril pretreated group revealed less structural damage as compared to STZ-diabetic rats. However lisinopril haul no effect on blood sugar i.e., it did not alter the diabetic state. It is concluded that lisinopril prevents the development of experimental diabetic neuropathy in STZ-induced diabetic rats. (C) 2001 Prous Science. All rights reserved.

引用

页码：131 / 134

页数：4

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