Headspace GC/MS testing for chlorodifluoromethane in two fatal cases

被引:5
作者
Kintz, P [1 ]
Baccino, E [1 ]
Tracqui, A [1 ]
Mangin, P [1 ]
机构
[1] CHU A MORVAN,SERV SEBILEAU,UNITE MED LEGALE,F-29609 BREST,FRANCE
关键词
chlorofluoromethane; Freon; 22; fluorocarbon; fatal poisoning;
D O I
10.1016/0379-0738(96)01992-5
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
Two cases of lethal poisoning due to chlorodifluoromethane (Freon 22) inhalation are described. The fluorocarbon was determined in biological tissues by headspace gas chromatography/mass spectrometry. Ions monitored were m/z 67, 86 and 51, the latter being used for quantification. Blood concentrations were 26.0 and 37.1 mu/ml. In both cases, the drug was also identified in urine, vitreous humor and bile, but in much lower concentrations.
引用
收藏
页码:171 / 175
页数:5
相关论文
共 10 条
[1]   GAS CHROMATOGRAPHY-MASS SPECTROMETRY OF FLUOROCARBONS 11 AND 12 IN BIOLOGIC SPECIMENS [J].
BACKER, RC ;
PISANO, RV .
CLINICAL TOXICOLOGY, 1978, 12 (01) :69-75
[2]  
BASELT R C, 1968, Journal of Forensic Sciences, V13, P407
[3]  
CLARK MA, 1985, J FORENSIC SCI, V30, P1256
[4]  
*ECETOC, 1989, JOINT ASS COMM CHEM, V9
[5]  
FITZGERALD RL, 1993, J FORENSIC SCI, V38, P476
[6]  
GROPPI A, 1994, J FORENSIC SCI, V39, P871
[7]   A REPORT OF OCCUPATIONAL DEATHS ATTRIBUTED TO FLUOROCARBON-113 [J].
MAY, DC ;
BLOTZER, MJ .
ARCHIVES OF ENVIRONMENTAL HEALTH, 1984, 39 (05) :352-354
[8]   CASE-REPORT OF DEATHS CAUSED BY FREON GAS [J].
MORITA, M ;
MIKI, A ;
KAZAMA, H ;
SAKATA, M .
FORENSIC SCIENCE, 1977, 10 (03) :253-260
[9]  
TSATSAKIS AM, 1991, TIAFT B, V21, P33
[10]   HUMAN INHALATION PHARMACOKINETICS OF CHLORODIFLUOROMETHANE (HCFC22) [J].
WOOLLEN, BH ;
MARSH, JR ;
MAHLER, JD ;
AUTON, TR ;
MAKEPEACE, D ;
COCKER, J ;
BLAIN, PG .
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 1992, 64 (05) :383-387