A single-nucleotide polymorphism in the sterol-regulatory element-binding protein 1c gene is predictive of HIV-related hyperlipoproteinaemia

被引：62

作者：

Miserez, AR ^{[1
]}

Muller, PY

Barella, L

Schwietert, M

Erb, P

Vernazza, PL

Battegay, M

机构：

[1] Univ Basel, Dept Clin Biol Sci, Basel, Switzerland

[2] Univ Basel, Inst Med Microbiol, Basel, Switzerland

[3] Univ Basel Hosp, Div Endocrinol Diabetol & Clin Nutr, CH-4031 Basel, Switzerland

[4] Univ Basel Hosp, Dept Internal Med, CH-4031 Basel, Switzerland

[5] Cantonal Hosp, Dept Med, St Gallen, Switzerland

来源：

AIDS | 2001年 / 15卷 / 15期

关键词：

D O I：

10.1097/00002030-200110190-00020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A single-nucleotide polymorphism (3'322C/G) was identified in the gene encoding a key cholesterol/triglyceride regulator, sterol-regulatory element-binding protein 1c (SREBP-1c). Although it did not alter the amino acid sequence, SREBP-1c-3'322C/G was predictive of highly active antiretroviral therapy-related hyperlipoproteinaemia. Increases in cholesterol were less frequently associated with homozygous SPEBP-1c-3'322G (genotype 22) than with heterozygous/homozygous SR-EBP-1c-3'322C (genotypes 11/12) and correlated with leptin and insulin increases, particularly in genotype 11/12 carriers. A functional mutation linked to SREBP-1c-3'322C/G or messenger RNA conformation differences may explain our findings.

引用

收藏

页码：2045 / 2049

页数：5

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