A two-step synthesis of terbinafine

被引：35

作者：

Alami, M

Ferri, F

Gaslain, Y

机构：

[1] Département de Chimie, Ecole Normale Supérieure, 75231 Paris Cedex 05

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 01期

关键词：

terbinafine; amino vinyl chlorides; amino enynes; palladium;

D O I：

10.1016/0040-4039(95)02095-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and high yielding synthesis of terbinafine 1a and amino enyne derivatives 1b-f is described from amino vinyl chlorides 2a-b and 1-alkynes in the presence of a weak ligated palladium complex: PdCl2(PhCN)(2) in piperidine.

引用

页码：57 / 58

页数：2

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