Dermatomyositis associated with invasive thymoma

被引：13

作者：

Ago, T ^{[1
]}

Nakamura, M ^{[1
]}

Iwata, I ^{[1
]}

Murai, H ^{[1
]}

Okuma, K ^{[1
]}

Tsuru, T ^{[1
]}

Kaji, Y ^{[1
]}

Hayashida, K ^{[1
]}

Niho, Y ^{[1
]}

机构：

[1] Kyushu Univ, Fac Med, Dept Internal Med 1, Higashi Ku, Fukuoka 8128582, Japan

来源：

INTERNAL MEDICINE | 1999年 / 38卷 / 02期

关键词：

myasthenia gravis; dermatomyositis; thymoma;

D O I：

10.2169/internalmedicine.38.155

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of dermatomyositis (DM) associated with invasive thymoma in a 22-year-old woman who was admitted to our hospital complaining of dyspnea which required ventilation support, The reddened elevated scaly eruptions were prominent over the extensor surfaces. Chest X-ray and computed tomography showed mediastinal masses, which were diagnosed as mixed type thymoma, Muscle and skin biopsy specimens were compatible with DM, She was treated with methylprednisolone pulse therapy followed by extended removal of the anterior mediastinal tumor and subsequent radiotherapy. She has had a good clinical course without recurrence of thymoma or DM for more than 3 years. The role of thymoma in the development of DM is discussed.

引用

页码：155 / 159

页数：5

共 15 条

[1] ASSOCIATION OF MYASTHENIA-GRAVIS AND POLYMYOSITIS WITH NEOPLASIA, INFECTION AND AUTOIMMUNE DISORDERS [J].

BEHAN, WMH ;

BEHAN, PO ;

DOYLE, D .

ACTA NEUROPATHOLOGICA, 1982, 57 (2-3) :221-229

[2] T-CELL RECEPTOR REPERTOIRE IN POLYMYOSITIS - CLONAL EXPANSION OF AUTOAGGRESSIVE CD8(+) T-CELLS [J].

BENDER, A ;

ERNST, N ;

IGLESIAS, A ;

DORNMAIR, K ;

WEKERLE, H ;

HOHLFELD, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (05) :1863-1868

[3] POLYMYOSITIS PRESENTING WITH RESPIRATORY-FAILURE [J].

BLUMBERGS, PC ;

BYRNE, E ;

KAKULAS, BA .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1984, 65 (02) :221-229

[4] POLYMYOSITIS AND DERMATOMYOSITIS .2. [J].

BOHAN, A ;

PETER, JB .

NEW ENGLAND JOURNAL OF MEDICINE, 1975, 292 (08) :403-407

[5] POLYMYOSITIS AND DERMATOMYOSITIS .1. [J].

BOHAN, A ;

PETER, JB .

NEW ENGLAND JOURNAL OF MEDICINE, 1975, 292 (07) :344-347

[6] RESPONSE OF THYMOMA TO STEROIDS [J].

GREEN, JD ;

FORMAN, WH .

CHEST, 1974, 65 (01) :114-116

[7] GENE REARRANGEMENTS IN LYMPHOMA - APPLICATIONS TO DERMATOPATHOLOGY [J].

LEBOIT, PE ;

PARSLOW, TG .

AMERICAN JOURNAL OF DERMATOPATHOLOGY, 1987, 9 (03) :212-218

[8]

LEBOIT PE, 1987, AM J DERMATOPATH, V9, P463

[9] ANALYSIS OF T-CELL RECEPTOR REPERTOIRE OF MUSCLE-INFILTRATING T-LYMPHOCYTES IN POLYMYOSITIS - RESTRICTED V-ALPHA/BETA REARRANGEMENTS MAY INDICATE ANTIGEN-DRIVEN SELECTION [J].

MANTEGAZZA, R ;

ANDREETTA, F ;

BERNASCONI, P ;

BAGGI, F ;

OKSENBERG, JR ;

SIMONCINI, O ;

MORA, M ;

CORNELIO, F ;

STEINMAN, L .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (06) :2880-2886

[10] Mechanisms of tolerance to self [J].

Miller, JFAP ;

Basten, A .

CURRENT OPINION IN IMMUNOLOGY, 1996, 8 (06) :815-821

← 1 2 →