A magic bullet for mucosal protection ... and aspirin is the trigger!

被引：41

作者：

Wallace, JL

Fiorucci, S

机构：

[1] Univ Calgary, Dept Pharmacol & Therapeut, Calgary, AB T2N 4N1, Canada

[2] Univ Perugia, Dept Gastroenterol, I-06100 Perugia, Italy

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2003年 / 24卷 / 07期

关键词：

D O I：

10.1016/S0165-6147(03)00166-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aspirin can induce gastric ulcers, largely because it inhibits the synthesis of gastroprotective prostaglandins. Co-administration of aspirin and a selective cyclooxygenase 2 inhibitor results in more gastric damage than that induced following administration of either drug alone. This is because aspirin triggers the cyclooxygenase-2-dependent synthesis of 15(R)-epi-lipoxin A(4), a substance that acts to diminish injury to the stomach. Lipoxins can also be produced independently of the actions of aspirin on cyclooxygenase 2, and might enhance epithelial integrity in various mucosal tissues.

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收藏

页码：323 / 326

页数：4

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