Fluorescence imaging of tumors in vivo

被引：187

作者：

Ballou, B

Ernst, LA

Waggoner, AS

机构：

[1] Carnegie Mellon Univ, Mol Biosensor & Imaging Ctr, Pittsburgh, PA 15213 USA

[2] Carnegie Mellon Univ, Dept Biol, Pittsburgh, PA 15213 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2005年 / 12卷 / 07期

关键词：

animals; antibodies; monoclonal; antigens; neoplasm; fluorescent dyes; green fluorescent protein; imaging; nanotechnology; quantum dots;

D O I：

10.2174/0929867053507324

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We review recent progress in tumor imaging in vivo using fluorescent tags, highlight the problems of fluorescence imaging in small animals, discuss recent advances in near-infrared fluorochromes and quantum dots, and point to some future possibilities. GFP-based fluorescence imaging is briefly discussed. The authors believe that improvements in near-infrared fluorochromes are required to enable practical imaging in tissues at centimeter depths.

引用

收藏

页码：795 / 805

页数：11

相关论文

共 135 条

[1] Green fluorescent protein as a scaffold for intracellular presentation of peptides [J].

Abedi, MR ;

Caponigro, G ;

Kamb, A .

NUCLEIC ACIDS RESEARCH, 1998, 26 (02) :623-630

[2] Synthesis, in vitro receptor binding, and in vivo evaluation of fluorescein and carbocyanine peptide-based optical contrast agents [J].

Achilefu, S ;

Jimenez, HN ;

Dorshow, RB ;

Bugaj, JE ;

Webb, EG ;

Wilhelm, RR ;

Rajagopalan, R ;

Johler, J ;

Erion, JL .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (10) :2003-2015

[3] Nanocrystal targeting in vivo [J].

Åkerman, ME ;

Chan, WCW ;

Laakkonen, P ;

Bhatia, SN ;

Ruoslahti, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12617-12621

[4] Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model [J].

Arap, W ;

Pasqualini, R ;

Ruoslahti, E .

SCIENCE, 1998, 279 (5349) :377-380

[5] Targeting the prostate for destruction through a vascular address [J].

Arap, W ;

Haedicke, W ;

Bernasconi, M ;

Kain, R ;

Rajotte, D ;

Krajewski, S ;

Ellerby, HM ;

Bredesen, DE ;

Pasqualini, R ;

Ruoslahti, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1527-1531

[6] New fluorescent markers for the red region [J].

Arden-Jacob, J ;

Frantzeskos, J ;

Kemnitzer, NU ;

Zilles, A ;

Drexhage, KH .

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2001, 57 (11) :2271-2283

[7] Circular permutation and receptor insertion within green fluorescent proteins [J].

Baird, GS ;

Zacharias, DA ;

Tsien, RY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11241-11246

[8] Cyanine fluorochrome-labeled antibodies in vivo: Assessment of tumor imaging using Cy3, Cy5, Cy5.5, and Cy7 [J].

Ballou, B ;

Fisher, GW ;

Deng, JS ;

Hakala, TR ;

Srivastava, M ;

Farkas, DL .

CANCER DETECTION AND PREVENTION, 1998, 22 (03) :251-257

[9] Tumor detection and visualization using cyanine fluorochrome-labeled antibodies [J].

Ballou, B ;

Fisher, GW ;

Hakala, TR ;

Farkas, DL .

BIOTECHNOLOGY PROGRESS, 1997, 13 (05) :649-658

[10] Noninvasive imaging of quantum dots in mice [J].

Ballou, B ;

Lagerholm, BC ;

Ernst, LA ;

Bruchez, MP ;

Waggoner, AS .

BIOCONJUGATE CHEMISTRY, 2004, 15 (01) :79-86

← 1 2 3 4 5 6 7 8 9 10 →