Perspective: Evolution and detection of genetic robustness

被引:504
作者
de Visser, JAGM
Hermisson, J
Wagner, GP
Meyers, LA
Bagheri, HC
Blanchard, JL
Chao, L
Cheverud, JM
Elena, SF
Fontana, W
Gibson, G
Hansen, TF
Krakauer, D
Lewontin, RC
Ofria, C
Rice, SH
von Dassow, G
Wagner, A
Whitlock, MC
机构
[1] Univ Wageningen & Res Ctr, Dept Genet, NL-6703 BD Wageningen, Netherlands
[2] Univ Munich, Dept Biol 2, D-80333 Munich, Germany
[3] Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT 06520 USA
[4] Univ Texas, Austin, TX 78712 USA
[5] Santa Fe Inst, Santa Fe, NM 87501 USA
[6] Natl Ctr Genome Resources, Santa Fe, NM 87501 USA
[7] Univ Calif San Diego, La Jolla, CA 92093 USA
[8] Washington Univ, Dept Anat & Neurobiol, St Louis, MO 63130 USA
[9] CSIC, Inst Biol Mol & Celular Plantas, Valencia 46022, Spain
[10] N Carolina State Univ, Dept Genet, Raleigh, NC 27695 USA
[11] Florida State Univ, Dept Biol Sci, Tallahassee, FL 32306 USA
[12] Harvard Univ, Museum Comparat Zool, Cambridge, MA 02138 USA
[13] Harvard Univ, Dept Populat Biol, Cambridge, MA 02138 USA
[14] Michigan State Univ, Ctr Microbial Ecol, E Lansing, MI 48324 USA
[15] Univ Washington, Friday Harbor Labs, Friday Harbor, WA 98250 USA
[16] Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA
[17] Univ British Columbia, Dept Zool, Vancouver, BC V6T 1Z4, Canada
关键词
canalization; environmental robustness; epistasis; evolvability; genetic robustness;
D O I
10.1554/02-750R
中图分类号
Q14 [生态学(生物生态学)];
学科分类号
071012 ; 0713 ;
摘要
Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding, metabolic flux, physiological homeostasis, development, and even organismal fitness. The mechanisms underlying robustness are diverse, ranging from thermodynamic stability at the RNA and protein level to behavior at the organismal level. Phenotypes can be robust either against heritable perturbations (e.g., mutations) or nonheritable perturbations (e.g., the weather). Here we primarily focus on the first kind of robustness-genetic robustness-and survey three growing avenues of research: (1) measuring genetic robustness in nature and in the laboratory; (2) understanding the evolution of genetic robustness; and (3) exploring the implications of genetic robustness for future evolution.
引用
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页码:1959 / 1972
页数:14
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