Metabotropic glutamate receptor activation selectively limits excitotoxic damage in the intact neostriatum

被引：20

作者：

Colwell, CS

Altemus, KL

Levine, MS

机构：

[1] Mental Retardation Research Center, Univ. of California at Los Angeles, Los Angeles, CA 90024-1759

来源：

BRAIN RESEARCH | 1996年 / 726卷 / 1-2期

关键词：

apomorphine; excitotoxicity; kainate; neostriatum; N-methyl-D-aspartate; metabotropic glutamate receptor; quinolinic acid;

D O I：

10.1016/0006-8993(96)00479-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study was designed to compare the protective consequences of activation of metabotropic glutamate receptors (mGluRs) on N-methyl-D-aspartate (NMDA)- and kainic acid (KA)-induced excitotoxicity in vivo. Pretreatment with the mGluR agonist 1SR,3RS-1-aminocyclo-pentane-1,3-dicarboxylic acid (tACPD) limited the anatomical and behavioral consequences of the intrastriatal administration of the NMDA agonist quinolinic acid (QA). In contrast, pretreatment with tACPD did not alter the effects of intrastriatal injection of KA.

引用

页码：223 / 226

页数：4

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