Ataxia telangiectasia: Cell signaling, cell death and the cell cycle

被引：9

作者：

Heintz, N

机构：

来源：

CURRENT OPINION IN NEUROLOGY | 1996年 / 9卷 / 02期

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D O I：

10.1097/00019052-199604000-00014

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cloning of the gene responsible for ataxia telangiectasia is a landmark achievement in the study of this devastating disease. The specific properties of the product of the mutation causing ataxia telangiectasia and the clinical features of this disease place this protein at the centre of a cell cycle checkpoint critical for DNA damage and suggest a fundamental mechanistic relationship between cell death and the cell cycle.

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页码：137 / 140

页数：4

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