Mesenchymal Stem Cells: A New Promise in Anticancer Therapy

被引：42

作者：

Ciavarella, Sabino ^{[1
]}

Dominici, Massimo ^{[1
]}

Dammacco, Franco ^{[1
]}

Silvestris, Franco ^{[1
]}

机构：

[1] Univ Bari, Sch Med, Dept Internal Med & Clin Oncol, I-70124 Bari, Italy

来源：

STEM CELLS AND DEVELOPMENT | 2011年 / 20卷 / 01期

关键词：

MARROW STROMAL CELLS; APOPTOSIS-INDUCING LIGAND; LUNG METASTASIS MODEL; MOUSE XENOGRAFT MODEL; CANCER GENE-THERAPY; GROWTH IN-VIVO; BONE-MARROW; ANTITUMOR-ACTIVITY; UMBILICAL-CORD; TUMOR STROMA;

D O I：

10.1089/scd.2010.0223

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Novel cell-based and gene therapies represent promising approaches for the treatment of incurable diseases, including cancer. Following the success of the hematopoietic stem cell-based transplantation, other populations of adult progenitor cells, including mesenchymal stem cells (MSCs), have been identified as powerful therapeutic tools in humans. The intrinsic capability of MSCs to migrate toward injured tissues emphasizes their suitability to deliver anticancer agents for new clinical applications in addition to the tissue repairing capacity. Here, we revisit the experimental history of MSCs, the most exciting features of their biology in keeping with their promising applications in cell-based therapeutic strategies for cancer treatment.

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页码：1 / 10

页数：10

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