How rapidly do Epoxides nonspecifically form covalent bonds with Thiols in water?

被引：8

作者：

Albert, Brian I. ^{[1
]}

Koide, Kazunori ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

CHEMBIOCHEM | 2007年 / 8卷 / 16期

关键词：

D O I：

10.1002/cbic.200700365

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rating reaction rates. Due to some concerns about the reactivity of epoxides towards the most abundant and powerful nucleophiles, thiols, in a biological setting, we report kinetic data for the consumption of five common epoxide motifs in the presence of a thiol under biologically relevant conditions.

引用

页码：1912 / +

页数：5

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