Statistical evaluation of alternative models of human evolution

被引:392
作者
Fagundes, Nelson J. R.
Ray, Nicolas
Beaumont, Mark
Neuenschwander, Samuel
Salzano, Francisco M. [1 ]
Bonatto, Sandro L.
Excoffier, Laurent
机构
[1] Pontificia Univ Catolica Rio Grande do Sul, Fac Biociencias, Genom & Mol Biol Lab, BR-90619900 Porto Alegre, RS, Brazil
[2] Pontificia Univ Catolica Rio Grande do Sul, Dept Genet, BR-91501970 Porto Alegre, RS, Brazil
[3] Univ Bern, Inst Zool, Computat & Mol Populat Genet, CH-3012 Bern, Switzerland
[4] Univ Reading, Sch Anim & Microbial Sci, Reading RG6 6AJ, Berks, England
[5] Univ Lausanne, Dept Ecol & Evolut, CH-1015 Lausanne, Switzerland
关键词
bayesian analysis; DNA nuclear data; multiregional hypothesis; out of Africa hypothesis;
D O I
10.1073/pnas.0708280104
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
An appropriate model of recent human evolution is not only important to understand our own history, but it is necessary to disentangle the effects of demography and selection on genome diversity. Although most genetic data support the view that our species originated recently in Africa, it is still unclear if it completely replaced former members of the Homo genus, or if some interbreeding occurred during its range expansion. Several scenarios of modern human evolution have been proposed on the basis of molecular and paleontological data, but their likelihood has never been statistically assessed. Using DNA data from 50 nuclear loci sequenced in African, Asian and Native American samples, we show here by extensive simulations that a simple African replacement model with exponential growth has a higher probability (78%) as compared with alternative multiregional evolution or assimilation scenarios. A Bayesian analysis of the data under this best supported model points to an origin of our species approximate to 141 thousand years ago (Kya), an exit out-of-Africa approximate to 51 Kya, and a recent colonization of the Americas approximate to 10.5 Kya. We also find that the African replacement model explains not only the shallow ancestry of mtDNA or Y-chromosomes but also the occurrence of deep lineages at some autosomal loci, which has been formerly interpreted as a sign of interbreeding with Homo erectus.
引用
收藏
页码:17614 / 17619
页数:6
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