Higher levels of basal serial CSF cortisol in combat veterans with posttraumatic stress disorder

被引:79
作者
Baker, DG
Ekhator, NN
Kasckow, JW
Dashevsky, B
Horn, PS
Bednarik, L
Geracioti, TD
机构
[1] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92092 USA
[2] San Diego VA Healthcare Syst, Psychiat Serv, San Diego, CA USA
[3] Cincinnati VA Med Ctr, Psychiat Serv, Cincinnati, OH USA
[4] Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati, OH 45221 USA
[5] Univ Cincinnati, Dept Math, Cincinnati, OH 45221 USA
关键词
D O I
10.1176/appi.ajp.162.5.992
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Results of basal peripheral cortisol measures in posttraumatic stress disorder ( PTSD) have been variable. The authors' goal was to measure CSF cortisol concentrations, which more accurately reflect brain glucocorticoid exposure, in subjects with or without PTSD. Method: CSF was withdrawn from a subarachnoid catheter and plasma from a venous catheter, both indwelling, over a 6-hour interval to determine hourly plasma ACTH and cortisol concentrations and hourly CSF cortisol levels in eight well-characterized combat veterans with PTSD and eight matched healthy volunteers. Results: Mean CSF cortisol concentrations were significantly higher in the subjects with PTSD (3.18 ng/ml, SD = 0.33) than in the normal volunteers (2.33 ng/ml, SD = 0.50), largely due to higher CSF cortisol concentration nadirs. No group differences were observed in either plasma ACTH or peripheral ( plasma or urinary free) cortisol. CSF corticotropin-releasing hormone and CSF cortisol concentrations were positively and significantly correlated. Conclusions: Despite normal peripheral cortisol indexes in the veterans with PTSD, their CNS exposure to cortisol was greater than that of normal comparison subjects.
引用
收藏
页码:992 / 994
页数:3
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