Synthesis of water-soluble prodrugs of the cytotoxic agent combretastatin A4.

被引：43

作者：

Bedford, SB

Quarterman, CP

Rathbone, DL

Slack, JA

Griffin, RJ

Stevens, MFG

机构：

[1] ASTON MOLEC LTD,BIRMINGHAM B7 4EJ,W MIDLANDS,ENGLAND

[2] UNIV NEWCASTLE UPON TYNE,DEPT CHEM,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND

[3] UNIV NOTTINGHAM,CANC RES LABS,NOTTINGHAM NG7 2RD,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 02期

关键词：

D O I：

10.1016/0960-894X(95)00580-M

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Water-soluble phosphate and glycine carbamate prodrugs of the cytotoxic agent Combretastatin A4 (1) have been prepared. The phosphate prodrug was degraded slowly in plasma at 37 degrees C. The degradation was accelerated by the addition of alkaline phosphatase.

引用

收藏

页码：157 / 160

页数：4

相关论文

共 7 条

[1] SYNTHESIS OF WATER-SOLUBLE SUGAR-DERIVATIVES OF COMBRETASTATIN A-4 [J].

BROWN, RT ;

FOX, BW ;

HADFIELD, JA ;

MCGOWN, AT ;

MAYALARP, SP ;

PETTIT, GR ;

WOODS, JA .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1995, (05) :577-581

[2]

JOHNS RB, 1988, SYNTHESIS-STUTTGART, P142

[3] ANTINEOPLASTIC AGENTS .113. SYNTHESIS OF NATURAL (-)-COMBRETASTATIN [J].

PETTIT, GR ;

SINGH, SB ;

CRAGG, GM .

JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (18) :3404-3406

[4] ANTINEOPLASTIC AGENTS .145. ISOLATION AND STRUCTURE OF THE STRONG CELL-GROWTH AND TUBULIN INHIBITOR COMBRETASTATIN-A-4 [J].

PETTIT, GR ;

SINGH, SB ;

HAMEL, E ;

LIN, CM ;

ALBERTS, DS ;

GARCIAKENDALL, D .

EXPERIENTIA, 1989, 45 (02) :209-211

[5] ANTINEOPLASTIC AGENTS .291. ISOLATION AND SYNTHESIS OF COMBRETASTATINS A-4, A-5, AND A-6 [J].

PETTIT, GR ;

SINGH, SB ;

BOYD, MR ;

HAMEL, E ;

PETTIT, RK ;

SCHMIDT, JM ;

HOGAN, F .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (10) :1666-1672

[6] ANTINEOPLASTIC AGENTS .124. ISOLATION, STRUCTURE, AND SYNTHESIS OF COMBRETASTATIN-A-1 AND COMBRETASATIN-B-1, POTENT NEW INHIBITORS OF MICROTUBULE ASSEMBLY, DERIVED FROM COMBRETUM-CAFFRUM [J].

PETTIT, GR ;

SINGH, SB ;

NIVEN, ML ;

HAMEL, E ;

SCHMIDT, JM .

JOURNAL OF NATURAL PRODUCTS, 1987, 50 (01) :119-131

[7]

PETTIT GR, 1995, ANTI-CANCER DRUG DES, V108, P299