Early bone formation in human bone grafts treated with platelet-rich plasma: preliminary histomorphometric results

被引:70
作者
Thor, A. [1 ,2 ]
Franke-Stenport, V. [2 ,3 ]
Johansson, C. B. [2 ,4 ]
Rasmusson, L. [2 ,5 ]
机构
[1] Univ Uppsala Hosp, Dept Oral & Maxillofacial Surg, Inst Surg Sci, SE-75185 Uppsala, Sweden
[2] Gothenburg Univ, Sahlgrenska Acad, Inst Surg Sci, Dept Biomat, Gothenburg, Sweden
[3] Gothenburg Univ, Sahlgrenska Acad, Inst Surg Sci, Dept Prosthet Dent Dent Mat Sci, Gothenburg, Sweden
[4] Univ Orebro, Dept Technol, Orebro, Sweden
[5] Gothenburg Univ, Sahlgrenska Acad, Inst Surg Sci, Dept Oral & Maxillofacial Surg, Gothenburg, Sweden
关键词
D O I
10.1016/j.ijom.2007.05.023
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The aim of this study was to evaluate the effect of platelet-rich plasma (PRP) on early and late bone healing after autogenous maxillary sinus grafting. Eleven patients were subjected to sinus augmentation with particulated autogenous bone bilaterally with the addition of PRP in one side. Platelet counts in baseline whole blood and PRP were registered. Biopsies were taken in the grafted bone of the sinus area with trephine at 3 months (nine patients) and simultaneously a microimplant was installed in the same region. The micro-implants with surrounding bone were retrieved by biopsy at 6 months (seven patients). Undecalcified cut and ground sections were histomorphometrically analysed. Quantification of new and old bone in all biopsies was performed. The results of this histological study showed that significantly more new bone was formed at PRP-treated sites compared to controls after 3 months of healing. After 6 months, this effect could no longer be observed. This is in accordance with previous studies showing that PRP has a rather low regenerative capacity but may influence the early phase of bone healing. The additional value of PRP in autogenous bone grafts in the maxillary sinus is questionable.
引用
收藏
页码:1164 / 1171
页数:8
相关论文
共 41 条
[1]  
ADELL R, 1990, International Journal of Oral and Maxillofacial Implants, V5, P233
[2]  
Aghaloo TL, 2004, INT J ORAL MAX IMPL, V19, P59
[3]   Investigation of platelet-rich plasma in rabbit cranial defects: A pilot study [J].
Aghaloo, TL ;
Moy, PK ;
Freymiller, EG .
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2002, 60 (10) :1176-1181
[4]   Autologous platelets as a source of proteins for healing and tissue regeneration [J].
Anitua, E ;
Andia, I ;
Ardanza, B ;
Nurden, P ;
Nurden, AT .
THROMBOSIS AND HAEMOSTASIS, 2004, 91 (01) :4-15
[5]  
Anitua E, 1999, INT J ORAL MAX IMPL, V14, P529
[6]  
[Anonymous], 1994, JOMI
[7]  
Blomqvist JE, 1998, INT J ORAL MAX IMPL, V13, P758
[8]  
BOYNE PJ, 1980, J ORAL SURG, V38, P613
[9]   RECONSTRUCTION OF ALVEOLAR JAW BONE - AN EXPERIMENTAL AND CLINICAL-STUDY OF IMMEDIATE AND PREFORMED AUTOLOGOUS BONE-GRAFTS IN COMBINATION WITH OSSEOINTEGRATED IMPLANTS [J].
BREINE, U ;
BRANEMARK, PI .
SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY, 1980, 14 (01) :23-48
[10]   Effect of platelet-rich plasma on bone regeneration in autogenous bone graft [J].
Choi, BH ;
Im, CJ ;
Huh, JY ;
Suh, JJ ;
Lee, SH .
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2004, 33 (01) :56-59