The ins and outs of sphingolipid synthesis

被引：278

作者：

Futerman, AH ^{[1
]}

Riezman, H

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

[2] Univ Geneva, Dept Biochem, CH-1211 Geneva, Switzerland

来源：

TRENDS IN CELL BIOLOGY | 2005年 / 15卷 / 06期

基金：

以色列科学基金会;

关键词：

D O I：

10.1016/j.tcb.2005.04.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sphingolipids are ubiquitous components of eukaryotic cell membranes, where they play important roles in intracellular signaling and in membrane structure. Even though the biochemical pathway of sphingolipid synthesis and its compartmentalization between the endoplasmic reticulum and Golgi apparatus have been known for many years, the molecular identity of the enzymes in this pathway has only recently been elucidated. Here, we summarize progress in the identification and characterization of the enzymes, the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus, and discuss how regulating the synthesis of sphingolipids might impact upon their functions.

引用

页码：312 / 318

页数：7

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