Adaptor usage and Toll-like receptor signaling specificity

被引：132

作者：

Dunne, A ^{[1
]}

O'Neill, LAJ ^{[1
]}

机构：

[1] Trinity Coll Dublin, Dept Biochem, Dublin 2, Ireland

来源：

FEBS LETTERS | 2005年 / 579卷 / 15期

关键词：

Toll-like receptors; adaptors; innate immunity;

D O I：

10.1016/j.febslet.2005.04.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is now well established that Toll-like receptors (TLRs) act as primary sensors of microbial compounds. Details of the molecular mechanisms governing TLR responses are emerging steadily and our understanding of the signaling pathways activated these receptors has improved greatly over the last few years. Differences in adaptor usage, cellular localisation and signaling cascades have been elucidated. In this review we will summarize the current understanding of TLR signaling and its regulation. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：3330 / 3335

页数：6

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