The NF-kappa B/Rel and I kappa B gene families: Mediators of immune response and inflammation

被引：240

作者：

Wulczyn, FG ^{[1
]}

Krappmann, D ^{[1
]}

Scheidereit, C ^{[1
]}

机构：

[1] MAX DELBRUCK CTR MOL MED, D-13122 BERLIN, GERMANY

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 1996年 / 74卷 / 12期

关键词：

transcription factors; oncogenes; signal transduction; NF-kappa B; I kappa B;

D O I：

10.1007/s001090050078

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Two families of gene regulators play an important role in cellular signaling processes in vertebrates: the nuclear factor kappa B (NF-kappa B)/Rel group of transcription activators and their coevolved regulatory proteins, the inhibitors of kappa B (I kappa Bs). The biological functions of NF-kappa B comprise communication between cells, embryonal development, the response to stress, inflammation and viral infection, and the maintenance of cell type specific expression of genes. In several pathogenic conditions components of the NF-kappa B system are deregulated and could thus present potential diagnostic probes or targets for therapeutic intervention.

引用

收藏

页码：749 / 769

页数：21

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