Antioxidant and neurosedative properties of polyphenols and iridoids from Lippia alba

被引：57

作者：

Hennebelle, Thierry ^{[1
]}

Sahpaz, Sevser ^{[1
]}

Gressier, Bernard ^{[2
]}

Joseph, Henry ^{[3
]}

Bailleul, Francois ^{[1
]}

机构：

[1] Univ Lille 2, Fac Sci Pharmaceut & Biol, Lab Pharmacognosie, EA 1043, F-59000 Lille, France

[2] Univ Lille 2, Fac Sci Pharmaceut & Biol, Pharmacol Lab, F-59000 Lille, France

[3] Assoc Promot Plantes Med & Aromat Guadeloupe, Les Abymes, Guadeloupe, France

来源：

PHYTOTHERAPY RESEARCH | 2008年 / 22卷 / 02期

关键词：

Lippia alba; antioxidant; sedative; iridoid; phenylpropanoid; flavonoid;

D O I：

10.1002/ptr.2266

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The neurosedative and antioxidative properties of some major compounds isolated from a citral chemotype of Lippia alba were investigated. Binding assays were performed on two CNS inhibitory targets: benzodiazepine and GABA(A) receptors. The most active compound was luteolin-7-diglucuronide, with half maximal inhibitory concentrations (IC50) of 101 and 40 mu m, respectively. Fifteen compounds isolated from Lippia alba were tested for their radical scavenging capacities against DPPH. Four of the major compounds (verbascoside, calceolarioside E, luteolin-7-diglucuronide and theveside) were also tested for their antioxidant activity against superoxide radical-anion in cell-free (hypoxanthine-xanthine oxidase) and cellular (PMA-stimulated neutrophil granulocytes) systems. Copyright (C) 2007 John Wiley & Sons, Ltd.

引用

页码：256 / 258

页数：3

共 10 条

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