Development of a near infrared fluorescence catheter: operating characteristics and feasibility for atherosclerotic plaque detection

被引：26

作者：

Zhu, BH

Jaffer, FA

Ntziachristos, V

Weissleder, R

机构：

[1] Massachusetts Gen Hosp, Ctr Mol Imaging Res, Boston, MA 02129 USA

[2] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

[3] Massachusetts Gen Hosp, Donald W Reynolds Cardiovasc Clin Res Ctr, Boston, MA 02129 USA

[4] Massachusetts Gen Hosp, Dept Internal Med, Div Cardiol, Boston, MA 02114 USA

来源：

JOURNAL OF PHYSICS D-APPLIED PHYSICS | 2005年 / 38卷 / 15期

关键词：

D O I：

10.1088/0022-3727/38/15/024

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We present a one-dimensional optical fibre-based imaging catheter specifically developed for the atherosclerotic plaque detection of emerging novel near infrared fluorescence imaging agents. We show that femtomole amounts of fluorochromes can be detected, especially in the presence of a blood-free medium. We further studied the catheter responses for a wide range of laser powers and biologically relevant concentrations of fluorochrome. In vitro tissue-like phantoms and human carotid plaque specimen measurements further demonstrate the feasibility of atherosclerotic plaque detection.

引用

页码：2701 / 2707

页数：7

共 28 条

[1] LASER-INDUCED FLUORESCENCE SPECTROSCOPY OF NORMAL AND ATHEROSCLEROTIC HUMAN AORTA USING 306-310 NM EXCITATION [J].