Signal transduction pathways modulated by the D-2 subfamily of dopamine receptors

被引：50

作者：

Huff, RM

机构：

[1] Central Nervous System Research, Pharmacia and Upjohn Inc., Kalamazoo, MI 49001-0199

来源：

CELLULAR SIGNALLING | 1996年 / 8卷 / 06期

关键词：

dopamine receptors; G-proteins; cAMP; tyrosine kinases; mitogen activated protein kinases (MAPK);

D O I：

10.1016/S0898-6568(96)00074-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The D-2 subfamily of dopamine receptors includes D-2A, D-2B, D-3, and D-4 dopamine receptors. These receptors activate cellular effector systems, principally through pertussis toxin-sensitive G-proteins. Historically, D-2-like receptors in brain tissues were recognized as the dopamine receptor subtypes chat inhibit adenylyl cyclase. Recent studies, reviewed here, have shown that multiple effector systems can be activated by these receptors, and the potential involvement of these in dopaminergic neutrotransmission is discussed. Copyright (C) 1996 Elsevier Science Inc.

引用

页码：453 / 459

页数：7

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