Current status of bovine spongiform encephalopathy - A review

被引:12
作者
Brewer, MS [1 ]
机构
[1] Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA
关键词
D O I
10.1111/j.1745-4573.1999.tb00389.x
中图分类号
TS2 [食品工业];
学科分类号
0832 [食品科学与工程];
摘要
Bovine spongiform encephalopathy (BSE) is a fatal brain disease of cattle which is presumed to have originated from feeding meat and bone meal (MBM) manufactured from rendered scrapie-infected sheep. More than 170,000 cases of BSE have been identified in UK cattle since it was specifically diagnosed in 1986. Most are in dairy herds. This paper reviews the background of the disease, changes in rendering in the United Kingdom which appear to have led to the development of BSE in cattle, characteristics of the disease, the disease-causing agent (prions), related prion diseases in other species, the impact of genetics on prion disease, prion strains, species barriers to transmission, risk of Creutzfeld-Jakob disease to humans, inactivating prion infectivity, and tallow and gelatin production and safety. Efforts at controlling the disease in the United Kingdom and preventing the disease in the United States are also discussed.
引用
收藏
页码:97 / 117
页数:21
相关论文
共 87 条
[1]
*AABP, 1996, BOV SPONG ENC BSE FA
[2]
ALMOND J, 1996, SPEC FOR BSE JUN 23
[3]
ALMOND J, 1997, NATURE, V390, P660
[4]
ANDERSON R M, 1991
[5]
Transmission dynamics and epidemiology of BSE in British cattle [J].
Anderson, RM ;
Donnelly, CA ;
Ferguson, NM ;
Woolhouse, MEJ ;
Watt, CJ ;
Udy, HJ ;
MaWhinney, S ;
Dunstan, SP ;
Southwood, TRE ;
Wilesmith, JW ;
Ryan, JBM ;
Hoinville, LJ ;
Hillerton, JE ;
Austin, AR ;
Wells, GAH .
NATURE, 1996, 382 (6594) :779-788
[6]
ANDERSON RM, 1996, INT S SPONG ENC GEN
[7]
IDENTIFICATION OF 5 ALLELIC VARIANTS OF THE SHEEP PRP GENE AND THEIR ASSOCIATION WITH NATURAL SCRAPIE [J].
BELT, PBGM ;
MUILEMAN, IH ;
SCHREUDER, BEC ;
BOSDERUIJTER, J ;
GIELKENS, ALJ ;
SMITS, MA .
JOURNAL OF GENERAL VIROLOGY, 1995, 76 :509-517
[8]
BLANCHFIELD R, 1996, BOVINE SPONGIFORM EN
[9]
PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain [J].
Blattler, T ;
Brandner, S ;
Raeber, AJ ;
Klein, MA ;
Voigtlander, T ;
Weissmann, C ;
Aguzzi, A .
NATURE, 1997, 389 (6646) :69-73
[10]
How do prion proteins get to the brain? [J].
Bradbury, J .
LANCET, 1997, 350 (9079) :718-718