HIV-1 decreases the levels of neurotrophins in human lymphocytes

被引：28

作者：

Avdoshina, Valeriya ^{[1
]}

Garzino-Demo, Alfredo ^{[2
]}

Bachis, Alessia ^{[1
]}

Monaco, Maria C. G. ^{[3
]}

Maki, Pauline M. ^{[4
,5
]}

Tractenberg, Rochelle E. ^{[6
]}

Liu, Chenglong ^{[7
]}

Young, Mary A. ^{[7
]}

Mocchetti, Italo ^{[1
]}

机构：

[1] Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20057 USA

[2] Univ Maryland, Dept Microbiol & Immunol, Inst Human Virol, Baltimore, MD 21201 USA

[3] NINDS, Lab Mol Med & Neurosci, NIH, Bethesda, MD 20892 USA

[4] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA

[5] Univ Illinois, Dept Psychol, Chicago, IL 60680 USA

[6] Georgetown Univ, Med Ctr, Dept Neurol, Washington, DC 20057 USA

[7] Georgetown Univ, Med Ctr, Dept Med, Washington, DC 20057 USA

来源：

AIDS | 2011年 / 25卷 / 08期

关键词：

WOMENS INTERAGENCY HIV; CHEMOKINE RECEPTORS; ALZHEIMERS-DISEASE; BRAIN; BDNF; CELLS; EXPRESSION; THYMUS; ABUSE; SERUM;

D O I：

10.1097/QAD.0b013e32834671b3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neurotrophins control cell survival. Therefore, we examined whether HIV-1 reduces neurotrophin levels. Serum of HIV-positive individuals exhibited lower concentrations of brain-derived neurotrophic factor (BDNF), but not of other neurotrophins, than HIV-negative individuals. In addition, R5 and X4 strains of HIV-1 decreased BDNF expression in T cells. Our results support the hypothesis that reduced levels of BDNF may be a risk factor for T-cell apoptosis and for neurological complications associated with HIV-1 infection.

引用

页码：1126 / 1128

页数：3

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